| Gene Information | |
|---|---|
| Gene Name | MGST3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 152 |
| Protein Names | Microsomal glutathione S-transferase 3 (Microsomal GST-3) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20) (Microsomal glutathione S-transferase III) (Microsomal GST-III) |
| Target Name | microsomal glutathione s-transferase 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000143198 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14880 |
| Gene Card | MGST3 |
| Uniprot ID | O14880 |
| Pfam | PF01124 |
| In ASD | no |
| Allosteric Prediction | no (-0.645848383) |
| Ortholog in Animals | Alpaca_ MGST3 ( ortholog_one2one ) Dog_ MGST3 ( ortholog_one2one ) GuineaPig_ MGST3 ( ortholog_one2one ) Macaque_ MGST3 ( ortholog_one2one ) Mouse_ Mgst3 ( ortholog_one2one ) Pig_ MGST3 ( ortholog_one2one ) Rat_ AABR07014550.1 ( ortholog_one2many ) Rat_ Mgst3 ( ortholog_one2many ) Rabbit_ MGST3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LTC4S, MGST2, ALOX5AP |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:9278457}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1802087 rs1802088 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Membrane {ECO:0000269|PubMed:9278457}. |
| Mouse PG classification | NA |
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