| Gene Information | |
|---|---|
| Gene Name | PTPRF |
| Organism | Homo sapiens (Human) |
| Gene Length | 1907 |
| Protein Names | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000142949 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P10586 |
| Gene Card | PTPRF |
| Uniprot ID | P10586 |
| Pfam | PF00041; PF07679; PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.756236176) |
| Ortholog in Animals | Alpaca_ PTPRF ( ortholog_one2one ) Dog_ PTPRF ( ortholog_one2one ) GuineaPig_ PTPRF ( ortholog_one2one ) Macaque_ PTPRF ( ortholog_one2one ) Mouse_ Ptprf ( ortholog_one2one ) Pig_ PTPRF ( ortholog_one2one ) Rat_ Ptprf ( ortholog_one2one ) Rabbit_ PTPRF ( ortholog_one2one ) |
| Ohnologs | PTPRS, PTPRD |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LAR (X-ray 2.00A ) 2DJU (NMR - ) 2DN7 (NMR - ) 2EDX (NMR - ) 2EDY (NMR - ) 2YD5 (X-ray 2.20A ) 2YD8 (X-ray 2.05A ) 4N5U (X-ray 1.46A ) 6KR4 (X-ray 2.85A ) 6TPT (X-ray 3.20A ) 6TPU (X-ray 1.55A ) 6TPV (X-ray 1.80A ) 6TPW (X-ray 2.90A ) |
| DBSNP | rs1065775 rs3748796 rs3748800 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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