| Gene Information | |
|---|---|
| Gene Name | TG |
| Organism | Homo sapiens (Human) |
| Gene Length | 2768 |
| Protein Names | Thyroglobulin (Tg) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000042832 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | NA |
| Gene Card | TG |
| Uniprot ID | P01266 |
| Pfam | PF00135; PF07699; PF00086 |
| In ASD | no |
| Allosteric Prediction | yes (0.805896176) |
| Ortholog in Animals | Alpaca_ TG ( ortholog_one2one ) Dog_ TG ( ortholog_one2one ) GuineaPig_ TG ( ortholog_one2one ) Macaque_ TG ( ortholog_one2one ) Mouse_ Tg ( ortholog_one2one ) Pig_ TG ( ortholog_one2one ) Rat_ Tg ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, BCHE, NLGN3, CES1, CEL |
| Tissue | thyroid |
| Tissue Specificity | Specifically expressed in the thyroid gland. {ECO:0000269|PubMed:11082042, ECO:0000269|PubMed:19509106, ECO:0000269|PubMed:8626858}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6SCJ (EM 3.60A ) 7B75 (EM 3.20A ) |
| DBSNP | rs2069546 rs180222 rs2069547 rs2069548 rs180223 rs3739274 rs16904774 rs2076737 rs2229843 rs16893332 rs853326 rs143983705 rs1016185504 rs11992497 rs12549018 rs2076738 rs2069556 rs2069558 rs16904791 rs2069561 rs121912649 rs2069562 rs56230101 rs2076739 rs2076740 rs2069564 rs2069565 rs370991693 rs2069566 rs121912650 rs137854434 rs2272707 rs2069568 rs2069569 rs12114109 rs1133076 rs10091530 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11082042, ECO:0000269|PubMed:19509106, ECO:0000269|PubMed:8626858}. Note=Secreted into the thyroid follicle lumen (PubMed:19509106). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:8626858, PubMed:11082042). {ECO:0000269|PubMed:11082042, ECO:0000269|PubMed:19509106, ECO:0000269|PubMed:8626858}. |
| Mouse PG classification | HPG |
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