| Gene Information | |
|---|---|
| Gene Name | SMPD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) |
| Target Name | sphingomyelin phosphodiesterase 3 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000103056 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NY59 |
| Gene Card | SMPD3 |
| Uniprot ID | Q9NY59 |
| Pfam | PF03372 |
| In ASD | yes |
| Allosteric Prediction | yes (0.668261781) |
| Ortholog in Animals | Alpaca_ SMPD3 ( ortholog_one2one ) Dog_ SMPD3 ( ortholog_one2one ) GuineaPig_ SMPD3 ( ortholog_one2one ) Macaque_ SMPD3 ( ortholog_one2one ) Mouse_ Smpd3 ( ortholog_one2one ) Pig_ SMPD3 ( ortholog_one2one ) Rat_ Smpd3 ( ortholog_one2one ) Rabbit_ SMPD3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | small.intestine |
| Tissue Specificity | Predominantly expressed in brain. {ECO:0000269|PubMed:10823942}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5UVG (X-ray 1.85A ) |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:10823942}; Lipid-anchor {ECO:0000269|PubMed:10823942}. Cell membrane {ECO:0000269|PubMed:15051724}; Lipid-anchor {ECO:0000269|PubMed:15051724}. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:10823942). Localizes to plasma membrane in confluent contact-inhaibited cells (PubMed:15051724). |
| Mouse PG classification | NA |
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