| Gene Information | |
|---|---|
| Gene Name | TFF3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 80 |
| Protein Names | Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000160180 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q07654 |
| Gene Card | TFF3 |
| Uniprot ID | Q07654 |
| Pfam | PF00088 |
| In ASD | no |
| Allosteric Prediction | no (-0.696140865) |
| Ortholog in Animals | Alpaca_ TFF3 ( ortholog_one2one ) Dog_ TFF3 ( ortholog_one2one ) Macaque_ TFF3 ( ortholog_one2one ) Mouse_ Tff3 ( ortholog_one2one ) Pig_ TFF3 ( ortholog_one2one ) Rat_ Tff3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TFF1, TFF2 |
| Tissue | NA |
| Tissue Specificity | Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level). {ECO:0000269|PubMed:8346203, ECO:0000269|PubMed:8454642}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E9T (NMR - ) 1PE3 (NMR - ) 6V1C (X-ray 1.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8454642}. Cytoplasm {ECO:0000269|PubMed:10824705, ECO:0000269|PubMed:8454642}. |
| Mouse PG classification | NA |
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