| Gene Information | |
|---|---|
| Gene Name | TFF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 84 |
| Protein Names | Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2) |
| Target Name | trefoil factor-1 |
| Target Type | Clinical trial target |
| Gene Age | 168 ( ENSG00000160182 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P04155 |
| Gene Card | TFF1 |
| Uniprot ID | P04155 |
| Pfam | PF00088 |
| In ASD | no |
| Allosteric Prediction | no (-0.656045618) |
| Ortholog in Animals | Alpaca_ TFF1 ( ortholog_one2one ) Dog_ TFF1 ( ortholog_one2one ) Macaque_ TFF1 ( ortholog_one2one ) Mouse_ Tff1 ( ortholog_one2one ) Pig_ TFF1 ( ortholog_one2one ) Rat_ Tff1 ( ortholog_one2one ) Rabbit_ TFF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TFF3, TFF2 |
| Tissue | stomach |
| Tissue Specificity | Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level). {ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:16308573, ECO:0000269|PubMed:16718800, ECO:0000269|PubMed:17143957, ECO:0000269|PubMed:17242463, ECO:0000269|PubMed:3041593, ECO:0000269|PubMed:3838275}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1HI7 (NMR - ) 1PS2 (NMR - ) 6V1D (X-ray 2.40A ) |
| DBSNP | rs34795821 rs961505229 rs1203145163 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:3041593}. |
| Mouse PG classification | NA |
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