Gene Information
Gene NameTFEB
OrganismHomo sapiens (Human)
Gene Length476
Protein NamesTranscription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000112561 )
Evolutionary StageEumetazoa
AlphaFoldDBP19484
Gene CardTFEB
Uniprot IDP19484
PfamPF11851; PF00010; PF15951
In ASDno
Allosteric Predictionno (-0.165695327)
Ortholog in AnimalsAlpaca_ TFEB ( ortholog_one2many )
Dog_ TFEB ( ortholog_one2one )
GuineaPig_ TFEB ( ortholog_one2one )
Macaque_ TFEB ( ortholog_one2one )
Mouse_ Tfeb ( ortholog_one2one )
Pig_ TFEB ( ortholog_one2one )
Rat_ Tfeb ( ortholog_one2one )
Rabbit_ TFEB ( ortholog_one2one )
OhnologsTFE3, TFEC, MITF
ParalogsTFE3, TFEC, MITF
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:27184844, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:33691586, ECO:0000269|PubMed:35662396}. Cytoplasm, cytosol {ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:27184844, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:33691586, ECO:0000269|PubMed:35662396}. Lysosome membrane {ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22692423}. Note=Mainly present in the cytoplasm (PubMed:23434374, PubMed:33691586, PubMed:35662396). When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity by promoting interaction with 14-3-3 proteins, such as YWHAZ (PubMed:22343943, PubMed:22692423, PubMed:35662396). Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus (PubMed:21617040, PubMed:22576015, PubMed:23434374). The translocation to the nucleus is regulated by ATP13A2 (PubMed:23434374, PubMed:27278822). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22343943, PubMed:22692423). Exported from the nucleus in response to nutrient availability (PubMed:30120233). In macrophages, translocates into the nucleus upon live S.enterica infection (PubMed:27184844). {ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:27184844, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:33691586, ECO:0000269|PubMed:35662396}.;
Nucleus {ECO:0000269|PubMed:33691586}. Note=(Microbial infection) Following Coxsackievirus B3 infection, full length TFEB and viral protease 3C-mediated cleavage product are translocated from the cytoplasm to the nucleus. {ECO:0000269|PubMed:33691586}.
Mouse PG classificationNA
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