| Gene Information | |
|---|---|
| Gene Name | TF2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 316 |
| Protein Names | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q00403 |
| Gene Card | GTF2B |
| Uniprot ID | Q00403 |
| Pfam | PF08271; PF00382 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the inner cell mass forming the embryoblast (PubMed:24441171). Not detected in cells from the outer thin layer trophoblast (at protein level) (PubMed:24441171). {ECO:0000269|PubMed:24441171}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.599107(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1C9B (X-ray 2.65A ) 1DL6 (NMR - ) 1RLY (NMR - ) 1RO4 (NMR - ) 1TFB (NMR - ) 1VOL (X-ray 2.70A ) 2PHG (NMR - ) 5IY6 (EM 7.20A ) 5IY7 (EM 8.60A ) 5IY8 (EM 7.90A ) 5IY9 (EM 6.30A ) 5IYA (EM 5.40A ) 5IYB (EM 3.90A ) 5IYC (EM 3.90A ) 5IYD (EM 3.90A ) 5WH1 (X-ray 3.39A ) 6O9L (EM 7.20A ) 7EDX (EM 4.50A ) 7EG7 (EM 6.20A ) 7EG8 (EM 7.40A ) 7EG9 (EM 3.70A ) 7EGA (EM 4.10A ) 7EGB (EM 3.30A ) 7EGC (EM 3.90A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7LBM (EM 4.80A ) 7NVR (EM 4.50A ) 7NVS (EM 2.80A ) 7NVT (EM 2.90A ) 7NVU (EM 2.50A ) 7NVY (EM 7.30A ) 7NVZ (EM 7.20A ) 7NW0 (EM 6.60A ) |
| DBSNP | rs1804499 rs144944840 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12931194}. Chromosome {ECO:0000269|PubMed:24441171}. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171). {ECO:0000269|PubMed:24441171}. |
| Mouse PG classification | NA |
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