| Gene Information | |
|---|---|
| Gene Name | TF |
| Organism | Homo sapiens (Human) |
| Gene Length | 698 |
| Protein Names | Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) |
| Target Name | transferrin |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000091513 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P02787 |
| Gene Card | TF |
| Uniprot ID | P02787 |
| Pfam | PF00405 |
| In ASD | yes |
| Allosteric Prediction | yes (1.211555363) |
| Ortholog in Animals | Alpaca_ TF ( ortholog_one2one ) Macaque_ TF ( ortholog_one2one ) Mouse_ Trf ( ortholog_one2one ) Pig_ TF ( ortholog_one2one ) |
| Ohnologs | MELTF |
| Paralogs | LTF, MELTF, SRPRB |
| Tissue | liver |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A8E (X-ray 1.60A ) 1A8F (X-ray 1.80A ) 1B3E (X-ray 2.50A ) 1BP5 (X-ray 2.20A ) 1BTJ (X-ray 3.20A ) 1D3K (X-ray 1.80A ) 1D4N (X-ray 2.00A ) 1DTG (X-ray 2.40A ) 1FQE (X-ray 1.80A ) 1FQF (X-ray 2.10A ) 1JQF (X-ray 1.85A ) 1N7W (X-ray 2.20A ) 1N7X (X-ray 2.10A ) 1N84 (X-ray 2.05A ) 1OQG (X-ray 1.90A ) 1OQH (X-ray 2.40A ) 1RYO (X-ray 1.20A ) 1SUV (EM 7.50A ) 2HAU (X-ray 2.70A ) 2HAV (X-ray 2.70A ) 2O7U (X-ray 2.80A ) 2O84 (X-ray 2.60A ) 3FGS (X-ray 1.80A ) 3QYT (X-ray 2.80A ) 3S9L (X-ray 3.22A ) 3S9M (X-ray 3.32A ) 3S9N (X-ray 3.25A ) 3SKP (X-ray 1.70A ) 3V83 (X-ray 2.10A ) 3V89 (X-ray 3.10A ) 3V8X (X-ray 2.60A ) 3VE1 (X-ray 2.96A ) 4H0W (X-ray 2.40A ) 4X1B (X-ray 2.45A ) 4X1D (X-ray 2.80A ) 5DYH (X-ray 2.68A ) 5H52 (X-ray 3.00A ) 5WTD (X-ray 2.50A ) 5X5P (X-ray 2.70A ) 5Y6K (X-ray 2.86A ) 6CTC (X-ray 2.60A ) 6D03 (EM 3.68A ) 6D04 (EM 3.74A ) 6D05 (EM 3.80A ) 6JAS (X-ray 2.50A ) 6SOY (X-ray 2.75A ) 6SOZ (X-ray 3.42A ) 6UJ6 (X-ray 2.68A ) 7FFM (X-ray 3.06A ) 7FFU (X-ray 2.60A ) 7Q1L (X-ray 3.00A ) |
| DBSNP | rs41298293 rs8177318 rs41298977 rs121918681 rs1799830 rs1799899 rs8177238 rs41295774 rs1804498 rs2692696 rs121918679 rs41296590 rs1049296 rs1130537 rs121918678 rs121918677 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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