| Gene Information | |
|---|---|
| Gene Name | SLC4A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1093 |
| Protein Names | Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000050438 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q2Y0W8 |
| Gene Card | SLC4A8 |
| Uniprot ID | Q2Y0W8 |
| Pfam | PF07565; PF00955 |
| In ASD | no |
| Allosteric Prediction | no (-0.012594803) |
| Ortholog in Animals | Alpaca_ SLC4A8 ( ortholog_one2one ) Dog_ SLC4A8 ( ortholog_one2one ) GuineaPig_ SLC4A8 ( ortholog_one2one ) Macaque_ SLC4A8 ( ortholog_one2one ) Mouse_ Slc4a8 ( ortholog_one2one ) Pig_ SLC4A8 ( ortholog_one2one ) Rat_ Slc4a8 ( ortholog_one2one ) Rabbit_ SLC4A8 ( ortholog_one2one ) |
| Ohnologs | SLC4A7, SLC4A10 |
| Paralogs | SLC4A9, SLC4A3, SLC4A2, SLC4A4, SLC4A10, SLC4A5, SLC4A11, SLC4A7, SLC4A1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997, ECO:0000269|PubMed:17715183}.; [Isoform 1]: Expressed in the brain. {ECO:0000269|PubMed:18577713}.; [Isoform 4]: Expressed in the brain, heart and kidney. {ECO:0000269|PubMed:18577713}.; [Isoform 5]: Expressed in the brain, heart and kidney. {ECO:0000269|PubMed:18577713}. |
| Pharmacological Animal Models | 0.350380(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5JHO (X-ray 2.80A ) |
| DBSNP | rs35966334 rs12318785 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 3]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 4]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 5]: Cell membrane {ECO:0000269|PubMed:18577713}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |