| Gene Information | |
|---|---|
| Gene Name | NLGN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 848 |
| Protein Names | Neuroligin-3 (Gliotactin homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196338 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NZ94 |
| Gene Card | NLGN3 |
| Uniprot ID | Q9NZ94 |
| Pfam | PF00135 |
| In ASD | no |
| Allosteric Prediction | yes (0.385403901) |
| Ortholog in Animals | Alpaca_ NLGN3 ( ortholog_one2one ) Dog_ NLGN3 ( ortholog_one2one ) GuineaPig_ NLGN3 ( ortholog_one2one ) Macaque_ NLGN3 ( ortholog_one2one ) Mouse_ Nlgn3 ( ortholog_one2one ) Pig_ NLGN3 ( ortholog_one2one ) Rat_ Nlgn3 ( ortholog_one2one ) Rabbit_ NLGN3 ( ortholog_one2one ) |
| Ohnologs | NLGN4Y, NLGN4X, NLGN1, NLGN2 |
| Paralogs | NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, BCHE, TG, CES1, CEL |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:10767552, ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17854698 rs17854697 rs17857400 rs17857401 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Detected at both glutamatergic and GABAergic synapses. {ECO:0000250}. |
| Mouse PG classification | NA |
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