| Gene Information | |
|---|---|
| Gene Name | TET2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2002 |
| Protein Names | Methylcytosine dioxygenase TET2 (EC 1.14.11.n2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000168769 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6N021 |
| Gene Card | TET2 |
| Uniprot ID | Q6N021 |
| Pfam | PF12851 |
| In ASD | no |
| Allosteric Prediction | yes (0.251356324) |
| Ortholog in Animals | Alpaca_ TET2 ( ortholog_one2one ) Dog_ TET2 ( ortholog_one2one ) GuineaPig_ TET2 ( ortholog_one2one ) Macaque_ TET2 ( ortholog_one2one ) Mouse_ Tet2 ( ortholog_one2one ) Rat_ Tet2 ( ortholog_one2one ) Rabbit_ TET2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TET1, TET3 |
| Tissue | NA |
| Tissue Specificity | Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes. {ECO:0000269|PubMed:12646957, ECO:0000269|PubMed:19483684}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4NM6 (X-ray 2.03A ) 5D9Y (X-ray 1.97A ) 5DEU (X-ray 1.80A ) |
| DBSNP | rs12498609 rs111948941 rs773565437 rs114619974 rs146031219 rs6843141 rs569067880 rs61744960 rs17253672 rs201642693 rs376570662 rs753786455 rs144386291 rs4145756 rs34485921 rs532738858 rs778464072 rs75056899 rs769422572 rs761811530 rs898441677 rs771761785 rs749210253 rs62623390 rs142312318 rs34402524 rs146348065 rs2454206 rs62621450 rs1453845082 rs116519313 rs1417392445 rs767475870 rs1163887807 rs1316795626 rs1283441077 rs200971953 rs754215085 rs1406914931 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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