| Gene Information | |
|---|---|
| Gene Name | ELOVL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 314 |
| Protein Names | Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) |
| Target Name | elongation of very long chain fatty acids protein 4 |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000118402 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9GZR5 |
| Gene Card | ELOVL4 |
| Uniprot ID | Q9GZR5 |
| Pfam | PF01151 |
| In ASD | no |
| Allosteric Prediction | no (-0.479949314) |
| Ortholog in Animals | Alpaca_ ELOVL4 ( ortholog_one2one ) Dog_ ELOVL4 ( ortholog_one2one ) GuineaPig_ ELOVL4 ( ortholog_one2one ) Macaque_ ELOVL4 ( ortholog_one2one ) Mouse_ Elovl4 ( ortholog_one2one ) Pig_ ELOVL4 ( ortholog_one2one ) Rat_ Elovl4 ( ortholog_one2one ) Rabbit_ ELOVL4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ELOVL2, ELOVL5, ELOVL1, ELOVL7, ELOVL3, ELOVL6 |
| Tissue | skin, zone.of.skin, brain, testis |
| Tissue Specificity | Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. {ECO:0000269|PubMed:20937905}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777598 rs148594713 rs3812153 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03204}. |
| Mouse PG classification | NA |
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