| Gene Information | |
|---|---|
| Gene Name | TESC |
| Organism | Homo sapiens (Human) |
| Gene Length | 214 |
| Protein Names | Calcineurin B homologous protein 3 (Tescalcin) (TSC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000088992 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96BS2 |
| Gene Card | TESC |
| Uniprot ID | Q96BS2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.039267658) |
| Ortholog in Animals | Alpaca_ TESC ( ortholog_one2one ) Dog_ TESC ( ortholog_one2one ) GuineaPig_ TESC ( ortholog_one2one ) Macaque_ TESC ( ortholog_one2one ) Mouse_ Tescl ( ortholog_one2many ) Mouse_ Tesc ( ortholog_one2many ) Pig_ TESC ( ortholog_one2one ) Rat_ Tesc ( ortholog_one2many ) Rat_ Tescl ( ortholog_one2many ) Rabbit_ TESC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CIB1, CIB4, CHP1, CIB3, PPP3R1, CIB2, CHP2, PPP3R2 |
| Tissue | NA |
| Tissue Specificity | Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. {ECO:0000269|PubMed:11696366, ECO:0000269|PubMed:20060826}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18321853}. Cytoplasm {ECO:0000269|PubMed:18321853}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18321853}. Cell projection, lamellipodium {ECO:0000269|PubMed:11696366}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5}. Note=Colocalizes with SLC9A1 at the plasma membrane. {ECO:0000269|PubMed:18321853}. |
| Mouse PG classification | NA |
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