| Gene Information | |
|---|---|
| Gene Name | TOP3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1001 |
| Protein Names | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000177302 ) 3 ( ENSG00000284238 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q13472 |
| Gene Card | TOP3A |
| Uniprot ID | Q13472 |
| Pfam | PF01131; PF01751; PF01396; PF06839 |
| In ASD | no |
| Allosteric Prediction | no (-0.176230171) |
| Ortholog in Animals | Alpaca_ TOP3A ( ortholog_one2one ) Dog_ TOP3A ( ortholog_one2one ) GuineaPig_ TOP3A ( ortholog_one2one ) Macaque_ TOP3A ( ortholog_one2one ) Mouse_ Top3a ( ortholog_one2one ) Pig_ TOP3A ( ortholog_one2one ) Rat_ Top3a ( ortholog_one2one ) Rabbit_ TOP3A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TOP3B |
| Tissue | NA |
| Tissue Specificity | High expression is found in testis, heart, skeletal muscle and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4CGY (X-ray 2.85A ) 4CHT (X-ray 3.25A ) |
| DBSNP | rs376902371 rs28671051 rs9909732 rs9911283 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:29290614}. |
| Mouse PG classification | NA |
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