| Gene Information | |
|---|---|
| Gene Name | SPATA13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 652 |
| Protein Names | Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000182957 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96N96 |
| Gene Card | SPATA13 |
| Uniprot ID | Q96N96 |
| Pfam | PF00169; PF00621; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.971121632) |
| Ortholog in Animals | Alpaca_ SPATA13 ( ortholog_one2one ) Macaque_ SPATA13 ( ortholog_one2one ) Mouse_ Spata13 ( ortholog_one2one ) Rat_ Spata13 ( ortholog_one2one ) Rabbit_ SPATA13 ( ortholog_one2one ) |
| Ohnologs | ARHGEF9 |
| Paralogs | ARHGEF9, MCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV2, VAV3, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7330736 rs201402934 |
| Subcellular location [CC] | Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. |
| Mouse PG classification | NA |
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