| Gene Information | |
|---|---|
| Gene Name | TEC |
| Organism | Homo sapiens (Human) |
| Gene Length | 631 |
| Protein Names | Tyrosine-protein kinase Tec (EC 2.7.10.2) |
| Target Name | tyrosine-protein kinase tec |
| Target Type | Patented-recorded target |
| Gene Age | 645 ( ENSG00000135605 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42680 |
| Gene Card | TEC |
| Uniprot ID | P42680 |
| Pfam | PF00779; PF00169; PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.157077895) |
| Ortholog in Animals | Alpaca_ TEC ( ortholog_one2one ) Dog_ TEC ( ortholog_one2one ) GuineaPig_ TEC ( ortholog_one2one ) Macaque_ TEC ( ortholog_one2one ) Mouse_ Tec ( ortholog_one2one ) Pig_ TEC ( ortholog_one2one ) Rat_ Tec ( ortholog_one2one ) Rabbit_ TEC ( ortholog_one2one ) |
| Ohnologs | BTK, ITK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.014286(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LUL (NMR - ) |
| DBSNP | rs35374286 |
| Subcellular location [CC] | Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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