| Gene Information | |
|---|---|
| Gene Name | CRH |
| Organism | Homo sapiens (Human) |
| Gene Length | 196 |
| Protein Names | Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) |
| Target Name | corticoliberin |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000147571 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P06850 |
| Gene Card | CRH |
| Uniprot ID | P06850 |
| Pfam | PF00473 |
| In ASD | no |
| Allosteric Prediction | yes (1.035258097) |
| Ortholog in Animals | Alpaca_ CRH ( ortholog_one2one ) Dog_ CRH ( ortholog_one2one ) GuineaPig_ CRH ( ortholog_one2one ) Macaque_ CRH ( ortholog_one2one ) Mouse_ Crh ( ortholog_one2one ) Pig_ CRH ( ortholog_one2one ) Rat_ Crh ( ortholog_one2one ) Rabbit_ CRH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UCN |
| Tissue | NA |
| Tissue Specificity | Produced by the hypothalamus and placenta. {ECO:0000269|PubMed:2783917, ECO:0000269|PubMed:3262120}. |
| Pharmacological Animal Models | 0.110239(Chimpanzee);0.214982(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GO9 (NMR - ) 1GOE (NMR - ) 3EHT (X-ray 3.40A ) 3EHU (X-ray 1.96A ) 6P9X (EM 2.91A ) |
| DBSNP | rs748404250 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:P06296}. |
| Mouse PG classification | NA |
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