| Gene Information | |
|---|---|
| Gene Name | EREG |
| Organism | Homo sapiens (Human) |
| Gene Length | 169 |
| Protein Names | Proepiregulin [Cleaved into: Epiregulin (EPR)] |
| Target Name | epiregulin |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000124882 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14944 |
| Gene Card | EREG |
| Uniprot ID | O14944 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.15028475) |
| Ortholog in Animals | Alpaca_ EREG ( ortholog_one2one ) Dog_ EREG ( ortholog_one2one ) GuineaPig_ EREG ( ortholog_one2one ) Macaque_ EREG ( ortholog_one2one ) Mouse_ Ereg ( ortholog_one2one ) Pig_ EREG ( ortholog_one2one ) Rat_ Ereg ( ortholog_one2one ) Rabbit_ EREG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BTC, AREG, EPGN, TGFA, HBEGF |
| Tissue | bone.marrow |
| Tissue Specificity | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. {ECO:0000269|PubMed:9337852}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1K36 (NMR - ) 1K37 (NMR - ) 5E8D (X-ray 2.50A ) 5WB7 (X-ray 2.94A ) 7LEN (X-ray 2.90A ) 7LFR (X-ray 3.20A ) 7LFS (X-ray 3.50A ) |
| DBSNP | rs35275884 |
| Subcellular location [CC] | [Epiregulin]: Secreted, extracellular space {ECO:0000269|PubMed:9337852}.; [Proepiregulin]: Cell membrane {ECO:0000269|PubMed:9337852}; Single-pass type I membrane protein {ECO:0000269|PubMed:9337852}. |
| Mouse PG classification | NA |
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