| Gene Information | |
|---|---|
| Gene Name | TDP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 362 |
| Protein Names | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000111802 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95551 |
| Gene Card | TDP2 |
| Uniprot ID | O95551 |
| Pfam | PF03372 |
| In ASD | no |
| Allosteric Prediction | no (-0.724508534) |
| Ortholog in Animals | Alpaca_ TDP2 ( ortholog_one2one ) Dog_ TDP2 ( ortholog_one2one ) GuineaPig_ TDP2 ( ortholog_one2one ) Macaque_ TDP2 ( ortholog_one2one ) Mouse_ Tdp2 ( ortholog_one2one ) Pig_ TDP2 ( ortholog_one2one ) Rat_ Tdp2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003). {ECO:0000269|PubMed:10764746, ECO:0000269|PubMed:24658003}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5INO (X-ray 3.21A ) 5J3P (X-ray 3.10A ) 5J3S (X-ray 3.40A ) 6Q00 (X-ray 0.85A ) 6Q01 (X-ray 0.85A ) |
| DBSNP | rs35977478 rs2294689 rs17249952 rs77273535 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12743594}. Nucleus, PML body {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21921940}. Nucleus, nucleolus {ECO:0000269|PubMed:21921940}. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. {ECO:0000269|PubMed:21921940}.; Cytoplasm {ECO:0000269|PubMed:22908287}. Note=(Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. {ECO:0000269|PubMed:22908287}. |
| Mouse PG classification | LPG |
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