| Gene Information | |
|---|---|
| Gene Name | TDL |
| Organism | Homo sapiens (Human) |
| Gene Length | 54 |
| Protein Names | Apelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P0DMC3 |
| Gene Card | APELA |
| Uniprot ID | P0DMC3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the intima of blood vessels (PubMed:28137936). Expressed in endothelial cells in blood vessels in the heart and lung (PubMed:28137936). Expressed in cytotrophoblasts and syncytiotrophoblasts of first-trimester placental tissue and term placentas (at protein level) (PubMed:28663440). Not detected in smooth muscle cells or cardiomyocytes (at protein level) (PubMed:28137936). Expressed in kidney (PubMed:25639753). Expressed in blood vessels (PubMed:28137936). Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753). Most highly expressed in undifferentiated embryonic stem cell and is rapidly down-regulated during differentiation (PubMed:24316148). {ECO:0000269|PubMed:24316148, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936, ECO:0000269|PubMed:28663440}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7W0N (EM 4.21A ) 7W0O (EM 3.78A ) 7W0P (EM 3.16A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:24316148, ECO:0000269|PubMed:28137936}. Secreted, extracellular space {ECO:0000269|PubMed:28137936}. Note=Found in blood plasma (PubMed:28137936). Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy (By similarity). {ECO:0000250|UniProtKB:P0DMC4}. |
| Mouse PG classification | NA |
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