| Gene Information | |
|---|---|
| Gene Name | IL17RD |
| Organism | Homo sapiens (Human) |
| Gene Length | 739 |
| Protein Names | Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000144730 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NFM7 |
| Gene Card | IL17RD |
| Uniprot ID | Q8NFM7 |
| Pfam | PF16742; PF08357 |
| In ASD | no |
| Allosteric Prediction | no (-0.999912613) |
| Ortholog in Animals | Alpaca_ IL17RD ( ortholog_one2one ) Dog_ IL17RD ( ortholog_one2one ) GuineaPig_ IL17RD ( ortholog_one2one ) Macaque_ IL17RD ( ortholog_one2one ) Mouse_ Il17rd ( ortholog_one2one ) Pig_ IL17RD ( ortholog_one2one ) Rat_ Il17rd ( ortholog_one2one ) Rabbit_ IL17RD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL17RB, IL17RA, IL17RE, IL17RC |
| Tissue | NA |
| Tissue Specificity | Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells. {ECO:0000269|PubMed:12807873}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs184758350 rs6780995 rs17057718 rs369641068 rs145221454 rs587776980 rs587776979 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Cell membrane {ECO:0000269|PubMed:14742870}; Single-pass type I membrane protein {ECO:0000269|PubMed:14742870}. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; [Isoform 4]: Cytoplasm. |
| Mouse PG classification | LPG |
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