| Gene Information | |
|---|---|
| Gene Name | TDGF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 188 |
| Protein Names | Teratocarcinoma-derived growth factor 1 (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) |
| Target Name | teratocarcinoma-derived growth factor 1 |
| Target Type | Clinical trial target |
| Gene Age | 132 ( ENSG00000241186 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P13385 |
| Gene Card | TDGF1 |
| Uniprot ID | P13385 |
| Pfam | PF09443 |
| In ASD | no |
| Allosteric Prediction | no (-0.875434592) |
| Ortholog in Animals | Alpaca_ TDGF1 ( ortholog_one2one ) Dog_ TDGF1 ( ortholog_many2many ) Mouse_ Tdgf1 ( ortholog_one2many ) Rat_ Tdgf1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | TDGF1P3, EGFL7, EGFL8, CFC1, CFC1B |
| Tissue | kidney, spleen |
| Tissue Specificity | Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. {ECO:0000269|PubMed:18835250}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11130097 rs2293025 rs34501971 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18930707, ECO:0000269|PubMed:27881714}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18930707, ECO:0000269|PubMed:27881714}. Secreted {ECO:0000269|PubMed:27881714}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000269|PubMed:27881714}. |
| Mouse PG classification | NA |
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