Gene Information
Gene NameSUN5
OrganismHomo sapiens (Human)
Gene Length379
Protein NamesSUN domain-containing protein 5 (Sad1 and UNC84 domain-containing protein 5) (Sperm-associated antigen 4-like protein) (Testis and spermatogenesis-related gene 4 protein)
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000167098 )
Evolutionary StageEukaryota
AlphaFoldDBQ8TC36
Gene CardSUN5
Uniprot IDQ8TC36
PfamPF07738
In ASDno
Allosteric Predictionno (-1.348260584)
Ortholog in AnimalsAlpaca_ SUN5 ( ortholog_one2one )
Dog_ SUN5 ( ortholog_one2one )
GuineaPig_ SUN5 ( ortholog_one2one )
Macaque_ SUN5 ( ortholog_one2one )
Mouse_ Sun5 ( ortholog_one2one )
Pig_ SUN5 ( ortholog_one2one )
Rat_ Sun5 ( ortholog_one2one )
Rabbit_ SUN5 ( ortholog_one2one )
OhnologsNA
ParalogsSUN3, SPAG4, SUN1, SUN2
Tissuetestis
Tissue SpecificitySperm (at protein level) (PubMed:27640305). Widely expressed (PubMed:12621555). Conflictingly shown to be specifically expressed in testis (PubMed:21711156). {ECO:0000269|PubMed:12621555, ECO:0000269|PubMed:21711156, ECO:0000269|PubMed:27640305}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3746387  rs1133358  rs35216976  rs886041023  rs17123951  rs886041024  rs756459525  rs758335571  rs754130052 
Subcellular location [CC]Nucleus inner membrane {ECO:0000305|PubMed:27640305};
Single-pass membrane protein {ECO:0000250|UniProtKB:Q9DA32}. Golgi apparatus {ECO:0000250|UniProtKB:Q9DA32}. Note=During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling apparatus of the sperm during sperm head elongation and differentiation. In mature spermatozoa, is localized to the coupling apparatus of the sperm head and tail in the implementation fossa. {ECO:0000305|PubMed:27640305}.
Mouse PG classificationNA
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