| Gene Information | |
|---|---|
| Gene Name | TCP11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 503 |
| Protein Names | T-complex protein 11 homolog |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000124678 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WWU5 |
| Gene Card | TCP11 |
| Uniprot ID | Q8WWU5 |
| Pfam | PF05794 |
| In ASD | no |
| Allosteric Prediction | no (-1.275364773) |
| Ortholog in Animals | Alpaca_ TCP11 ( ortholog_one2one ) Dog_ TCP11 ( ortholog_one2one ) GuineaPig_ TCP11 ( ortholog_one2one ) Macaque_ TCP11 ( ortholog_one2one ) Mouse_ Tcp11 ( ortholog_one2one ) Pig_ TCP11 ( ortholog_one2one ) Rat_ Tcp11 ( ortholog_one2one ) Rabbit_ TCP11 ( ortholog_one2one ) |
| Ohnologs | TCP11L2, TCP11L1 |
| Paralogs | TCP11L2, TCP11X2, TCP11X1, TCP11L1 |
| Tissue | testis |
| Tissue Specificity | Isoform 2 and isoform 3 are expressed in sperm. Isoform 1 is not detected in sperm (at protein level) (PubMed:21597245). Testis-specific (PubMed:11756566). Isoform 1, isoform 2 and isoform 3 are expressed in sperm (PubMed:21597245). {ECO:0000269|PubMed:11756566, ECO:0000269|PubMed:21597245}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2234045 rs2234051 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q01755}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q01755}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250|UniProtKB:Q01755}. |
| Mouse PG classification | NA |
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