| Gene Information | |
|---|---|
| Gene Name | TCL1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 114 |
| Protein Names | T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000100721 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P56279 |
| Gene Card | TCL1A |
| Uniprot ID | P56279 |
| Pfam | PF01840 |
| In ASD | no |
| Allosteric Prediction | no (-1.000239024) |
| Ortholog in Animals | Alpaca_ TCL1A ( ortholog_one2one ) Macaque_ TCL1A ( ortholog_one2one ) Mouse_ Tcl1 ( ortholog_one2one ) Pig_ TCL1A ( ortholog_one2one ) Rat_ Tcl1a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TCL1B, MTCP1 |
| Tissue | lymph.node, tonsil, appendix, spleen |
| Tissue Specificity | Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JSG (X-ray 2.50A ) |
| DBSNP | rs17093294 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269|PubMed:7987816}. Endoplasmic reticulum {ECO:0000269|PubMed:7987816}. Note=Microsomal fraction. |
| Mouse PG classification | NA |
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