| Gene Information | |
|---|---|
| Gene Name | TCIRG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 830 |
| Protein Names | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) |
| Target Name | v-atpase subunits |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000110719 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q13488 |
| Gene Card | TCIRG1 |
| Uniprot ID | Q13488 |
| Pfam | PF01496 |
| In ASD | no |
| Allosteric Prediction | yes (0.535865115) |
| Ortholog in Animals | Alpaca_ TCIRG1 ( ortholog_one2one ) Dog_ TCIRG1 ( ortholog_one2one ) GuineaPig_ TCIRG1 ( ortholog_one2one ) Macaque_ TCIRG1 ( ortholog_one2one ) Mouse_ Tcirg1 ( ortholog_one2one ) Pig_ TCIRG1 ( ortholog_one2one ) Rat_ Tcirg1 ( ortholog_one2one ) |
| Ohnologs | ATP6V0A2 |
| Paralogs | ATP6V0A2, ATP6V0A4, ATP6V0A1 |
| Tissue | NA |
| Tissue Specificity | Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs36027301 rs34227834 rs137853150 rs137853151 rs771271907 rs369264588 |
| Subcellular location [CC] | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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