| Gene Information | |
|---|---|
| Gene Name | TCF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 667 |
| Protein Names | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000196628 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P15884 |
| Gene Card | TCF4 |
| Uniprot ID | P15884 |
| Pfam | PF00010 |
| In ASD | no |
| Allosteric Prediction | no (-0.563446468) |
| Ortholog in Animals | Alpaca_ TCF4 ( ortholog_one2one ) Dog_ TCF4 ( ortholog_one2one ) GuineaPig_ TCF4 ( ortholog_one2one ) Macaque_ TCF4 ( ortholog_one2one ) Mouse_ Tcf4 ( ortholog_one2one ) Pig_ TCF4 ( ortholog_one2one ) Rat_ Tcf4 ( ortholog_one2many ) Rabbit_ TCF4 ( ortholog_one2one ) |
| Ohnologs | TCF3, TCF12 |
| Paralogs | TCF3, TCF12 |
| Tissue | NA |
| Tissue Specificity | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KWF (NMR - ) 6OD3 (X-ray 1.49A ) 6OD4 (X-ray 1.70A ) 6OD5 (X-ray 2.05A ) |
| DBSNP | rs11660217 rs1057521070 rs121909123 rs121909123 rs121909121 rs121909120 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22777675}. |
| Mouse PG classification | NA |
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