| Gene Information | |
|---|---|
| Gene Name | SSTR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 369 |
| Protein Names | Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1) |
| Target Name | somatostatin receptor type 2 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000180616 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P30874 |
| Gene Card | SSTR2 |
| Uniprot ID | P30874 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.145195758) |
| Ortholog in Animals | Alpaca_ SSTR2 ( ortholog_one2one ) Dog_ SSTR2 ( ortholog_one2one ) Macaque_ SSTR2 ( ortholog_one2one ) Mouse_ Sstr2 ( ortholog_one2one ) Pig_ SSTR2 ( ortholog_one2one ) Rat_ Sstr2 ( ortholog_one2one ) Rabbit_ SSTR2 ( ortholog_one2one ) |
| Ohnologs | OPRL1, MCHR1, MCHR2, SSTR5 |
| Paralogs | SSTR5, SSTR4, NPBWR1, OPRL1, GPR149, OPRM1, OPRK1, PTGDR2, SSTR3, CMKLR2, SSTR1, LTB4R, LTB4R2, KISS1R, UTS2R, NPBWR2, OPRD1 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. {ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22932785}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7T10 (EM 2.50A ) 7T11 (EM 2.70A ) 7UL5 (EM 3.10A ) 7WIC (EM 2.80A ) 7WIG (EM 2.70A ) 7WJ5 (EM 3.72A ) 7XAT (EM 2.85A ) 7XAU (EM 2.97A ) 7XAV (EM 2.87A ) 7XMR (EM 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm. |
| Mouse PG classification | NA |
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