| Gene Information | |
|---|---|
| Gene Name | TC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 106 |
| Protein Names | Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NR00 |
| Gene Card | TCIM |
| Uniprot ID | Q9NR00 |
| Pfam | PF15063 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347). {ECO:0000269|PubMed:11056052, ECO:0000269|PubMed:24941347, ECO:0000269|PubMed:25985737}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6474226 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:25985737}. Nucleus, nucleolus {ECO:0000269|PubMed:16424001}. Nucleus speckle {ECO:0000269|PubMed:16424001}. Nucleus {ECO:0000269|PubMed:16424001}. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:17603013}. |
| Mouse PG classification | NA |
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