| Gene Information | |
|---|---|
| Gene Name | GPER1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 375 |
| Protein Names | G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER) |
| Target Name | g-protein coupled estrogen receptor 1 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000164850 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q99527 |
| Gene Card | GPER1 |
| Uniprot ID | Q99527 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.63737949) |
| Ortholog in Animals | Dog_ GPER1 ( ortholog_one2one ) GuineaPig_ GPER1 ( ortholog_one2one ) Macaque_ GPER1 ( ortholog_one2one ) Mouse_ Gper1 ( ortholog_one2one ) Pig_ GPER1 ( ortholog_one2one ) Rat_ Gper1 ( ortholog_one2one ) Rabbit_ GPER1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPR182 |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. {ECO:0000269|PubMed:20203690, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:21149639, ECO:0000269|PubMed:21354433, ECO:0000269|PubMed:21427217, ECO:0000269|PubMed:23285008}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11544331 |
| Subcellular location [CC] | Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18566127}; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Postsynaptic density {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). {ECO:0000250}. |
| Mouse PG classification | NA |
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