Gene Information
Gene NameSLC22A8
OrganismHomo sapiens (Human)
Gene Length542
Protein NamesOrganic anion transporter 3 (hOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8)
Target Namesolute carrier family 22 member 8
Target TypeNA
Gene Age1488 ( ENSG00000149452 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ8TCC7
Gene CardSLC22A8
Uniprot IDQ8TCC7
PfamPF00083
In ASDno
Allosteric Predictionyes (0.27518087)
Ortholog in AnimalsAlpaca_ SLC22A8 ( ortholog_one2one )
GuineaPig_ SLC22A8 ( ortholog_one2one )
Macaque_ SLC22A8 ( ortholog_one2one )
Mouse_ Slc22a8 ( ortholog_one2one )
Pig_ SLC22A8 ( ortholog_one2one )
Rat_ Slc22a8 ( ortholog_one2one )
OhnologsSLC22A2, SLC22A7, SLC22A3, SLC22A1
ParalogsSLC22A24, SLC22A12, SLC22A1, SLC22A6, SVOP, SLC22A17, SLC22A7, SLC22A11, SLC22A23, SLC22A2, SLC22A25, SLC22A15, SLC22A9, SLC22A4, SLC22A5, SLC22A3, SLC22A16, SVOPL, SLC22A31, SLC22A13, SLC22A14, SLC22A10
Tissuekidney
Tissue SpecificityStrongly expressed in kidney (PubMed:11306713, PubMed:11912245). Weaker expression in brain and skeletal muscle (PubMed:11306713). Expressed in adrenal glands (PubMed:15864504). {ECO:0000269|PubMed:11306713, ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:15864504}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11568479  rs45566039  rs11568493  rs11568492  rs45438191  rs11568482  rs749944923  rs11568486 
Subcellular location [CC]Basolateral cell membrane {ECO:0000269|PubMed:11306713};
Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells (By similarity). Localizes to the basolateral membrane of the proximal tubular cells (PubMed:11306713). Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9R1U7, ECO:0000269|PubMed:11306713}.
Mouse PG classificationNA
click here to return to the previous page