| Gene Information | |
|---|---|
| Gene Name | TBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000112592 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P20226 |
| Gene Card | TBP |
| Uniprot ID | P20226 |
| Pfam | PF00352 |
| In ASD | no |
| Allosteric Prediction | yes (0.096623051) |
| Ortholog in Animals | Alpaca_ TBP ( ortholog_one2one ) Dog_ TBP ( ortholog_one2one ) GuineaPig_ TBP ( ortholog_one2one ) Macaque_ TBP ( ortholog_one2one ) Mouse_ Tbp ( ortholog_one2one ) Rat_ Tbp ( ortholog_one2one ) Rabbit_ TBP ( ortholog_one2one ) |
| Ohnologs | TBPL2 |
| Paralogs | TBPL1, TBPL2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with levels highest in the testis and ovary. {ECO:0000269|PubMed:17570761}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.244786(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1C9B (X-ray 2.65A ) 1CDW (X-ray 1.90A ) 1JFI (X-ray 2.62A ) 1NVP (X-ray 2.10A ) 1TGH (X-ray 2.90A ) 4ROC (X-ray 1.90A ) 4ROD (X-ray 2.70A ) 4ROE (X-ray 2.20A ) 5FUR (EM 8.50A ) 5IY6 (EM 7.20A ) 5IY7 (EM 8.60A ) 5IY8 (EM 7.90A ) 5IY9 (EM 6.30A ) 5IYA (EM 5.40A ) 5IYB (EM 3.90A ) 5IYC (EM 3.90A ) 5IYD (EM 3.90A ) 5N9G (X-ray 2.70A ) 6MZD (EM 9.80A ) 6MZL (EM 23.00A ) 6MZM (EM 7.50A ) 6O9L (EM 7.20A ) 7EDX (EM 4.50A ) 7EG7 (EM 6.20A ) 7EG8 (EM 7.40A ) 7EG9 (EM 3.70A ) 7EGA (EM 4.10A ) 7EGB (EM 3.30A ) 7EGC (EM 3.90A ) 7EGD (EM 6.75A ) 7EGE (EM 9.00A ) 7EGF (EM 3.16A ) 7EGI (EM 9.82A ) 7EGJ (EM 8.64A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7LBM (EM 4.80A ) 7NVR (EM 4.50A ) 7NVS (EM 2.80A ) 7NVT (EM 2.90A ) 7NVU (EM 2.50A ) 7NVY (EM 7.30A ) 7NVZ (EM 7.20A ) 7NW0 (EM 6.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:27007846}. |
| Mouse PG classification | HPG |
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