| Gene Information | |
|---|---|
| Gene Name | RBM20 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1227 |
| Protein Names | RNA-binding protein 20 (RNA-binding motif protein 20) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000203867 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5T481 |
| Gene Card | RBM20 |
| Uniprot ID | Q5T481 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.2931858) |
| Ortholog in Animals | Alpaca_ RBM20 ( ortholog_one2one ) Dog_ RBM20 ( ortholog_one2one ) GuineaPig_ RBM20 ( ortholog_one2one ) Macaque_ RBM20 ( ortholog_one2one ) Mouse_ Rbm20 ( ortholog_one2one ) Pig_ RBM20 ( ortholog_one2one ) Rat_ Rbm20 ( ortholog_one2one ) Rabbit_ RBM20 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HNRNPL, HNRNPLL, PTBP3, PTBP2, PTBP1 |
| Tissue | heart, pancreas, atrium, left.ventricle |
| Tissue Specificity | Mainly expressed in the heart (PubMed:19712804, PubMed:23886709). Also expressed in skeletal muscle tissues, ovary, small intestine and colon (PubMed:23886709). {ECO:0000269|PubMed:19712804, ECO:0000269|PubMed:23886709}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs536357058 rs7908490 rs397516621 rs940901720 rs771764951 rs189569984 rs183007628 rs267607001 rs796734066 rs267607002 rs267607004 rs267607002 rs267607005 rs267607003 rs1475557145 rs375798246 rs1417635 rs201370621 rs1564664312 rs397516607 rs727503392 rs199830512 rs1268330519 rs757389650 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:23886709, ECO:0000269|PubMed:30262925, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:33188278, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:33188278, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. Note=The active form that regulates alternative splicing localizes to the nucleus (PubMed:35427468, PubMed:33188278, PubMed:34732726). Also localizes to cytoplasmic ribonucleoprotein granules; localization to cytoplasmic ribonucleoprotein granules plays an important regulatory role (PubMed:35427468, PubMed:33188278, PubMed:34732726). Subcellular localization is regulated by phosphorylation of different parts of the protein: while phosphorylation of the RS (arginine/serine-rich) region promotes nuclear localization, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules (PubMed:35427468). {ECO:0000269|PubMed:33188278, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Mouse PG classification | HPG |
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