| Gene Information | |
|---|---|
| Gene Name | TBK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 729 |
| Protein Names | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) |
| Target Name | serine/threonine-protein kinase tbk1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000183735 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UHD2 |
| Gene Card | TBK1 |
| Uniprot ID | Q9UHD2 |
| Pfam | PF00069; PF18394; PF18396 |
| In ASD | no |
| Allosteric Prediction | yes (0.261278295) |
| Ortholog in Animals | Alpaca_ TBK1 ( ortholog_one2one ) Dog_ TBK1 ( ortholog_one2one ) GuineaPig_ TBK1 ( ortholog_one2one ) Macaque_ TBK1 ( ortholog_one2one ) Mouse_ Tbk1 ( ortholog_one2one ) Pig_ TBK1 ( ortholog_one2one ) Rat_ Tbk1 ( ortholog_one2one ) Rabbit_ TBK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IKBKE, IKBKB, CHUK |
| Tissue | NA |
| Tissue Specificity | Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina. {ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:21447600}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.184192(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4EFO (X-ray 1.77A ) 4EUT (X-ray 2.60A ) 4EUU (X-ray 1.80A ) 4IM0 (X-ray 2.40A ) 4IM2 (X-ray 2.50A ) 4IM3 (X-ray 3.34A ) 4IW0 (X-ray 4.00A ) 4IWO (X-ray 2.61A ) 4IWP (X-ray 3.06A ) 4IWQ (X-ray 3.00A ) 5EOA (X-ray 2.50A ) 5EOF (X-ray 2.05A ) 5EP6 (X-ray 1.45A ) 5W5V (X-ray 3.65A ) 6BNY (X-ray 3.34A ) 6BOD (X-ray 3.20A ) 6BOE (X-ray 3.60A ) 6CQ0 (X-ray 3.19A ) 6CQ4 (X-ray 3.20A ) 6CQ5 (X-ray 3.35A ) 6NT9 (EM 3.30A ) 6O8B (X-ray 3.40A ) 6RSR (X-ray 3.15A ) 6RST (X-ray 3.29A ) 6RSU (X-ray 2.75A ) |
| DBSNP | rs1010930015 rs1366668789 rs55824172 rs1555202947 rs1555203557 rs56196591 rs34774243 rs770942184 rs201970436 rs758357594 rs17857028 rs756751089 rs1262765773 rs35635889 rs17853341 rs765035140 rs899858451 rs748112833 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:21813773, ECO:0000269|PubMed:29251827}. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. {ECO:0000269|PubMed:17018283}. |
| Mouse PG classification | LPG |
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