| Gene Information | |
|---|---|
| Gene Name | AKAP12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1782 |
| Protein Names | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000131016 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q02952 |
| Gene Card | AKAP12 |
| Uniprot ID | Q02952 |
| Pfam | PF10522; PF03832 |
| In ASD | no |
| Allosteric Prediction | yes (0.063096623) |
| Ortholog in Animals | Alpaca_ AKAP12 ( ortholog_one2one ) Dog_ AKAP12 ( ortholog_one2one ) GuineaPig_ AKAP12 ( ortholog_one2one ) Macaque_ AKAP12 ( ortholog_one2one ) Mouse_ Akap12 ( ortholog_one2one ) Pig_ AKAP12 ( ortholog_one2one ) Rat_ Akap12 ( ortholog_one2one ) Rabbit_ AKAP12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10872670 rs3734799 rs552053449 rs13212161 rs1042069 rs3734797 rs9478198 rs12201388 rs3823310 rs3734795 |
| Subcellular location [CC] | Cytoplasm, cell cortex {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=May be part of the cortical cytoskeleton. |
| Mouse PG classification | NA |
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