Gene Information
Gene NameASAH1
OrganismHomo sapiens (Human)
Gene Length395
Protein NamesAcid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta]
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000104763 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ13510
Gene CardASAH1
Uniprot IDQ13510
PfamPF02275; PF15508
In ASDyes
Allosteric Predictionyes (0.849758917)
Ortholog in AnimalsAlpaca_ ASAH1 ( ortholog_one2one )
GuineaPig_ ASAH1 ( ortholog_one2one )
Macaque_ ASAH1 ( ortholog_one2one )
Mouse_ Asah1 ( ortholog_one2one )
Pig_ ASAH1 ( ortholog_one2one )
Rat_ Asah1 ( ortholog_one2one )
Rabbit_ ASAH1 ( ortholog_one2one )
OhnologsNA
ParalogsNAAA
TissueNA
Tissue SpecificityBroadly expressed with higher expression in heart. {ECO:0000269|PubMed:10610716}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5U7Z  (X-ray  2.50A  )  6MHM  (X-ray  2.74A  ) 
DBSNP rs137853595  rs779888892  rs145873635  rs10103355  rs1071645  rs1071645  rs1049874  rs2472205  rs137853594  rs200455852  rs756455049  rs137853597  rs137853593  rs1554808625  rs10103355  rs137853596  rs543697946  rs17636067  rs756455049  rs1588973202 
Subcellular location [CC]Lysosome {ECO:0000269|PubMed:12764132}. Secreted {ECO:0000269|PubMed:7744740}. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent. {ECO:0000269|PubMed:11451951}.;
[Isoform 2]: Nucleus {ECO:0000305|PubMed:22927646}. Cytoplasm {ECO:0000305|PubMed:22927646}. Note=A localization to the nucleus and the cytoplasm has also been reported for ASAH1, most probably for isoforms devoid of a signal peptide. {ECO:0000305|PubMed:22927646}.
Mouse PG classificationNA
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