Gene Information
Gene NameTBC1D21
OrganismHomo sapiens (Human)
Gene Length336
Protein NamesTBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000167139 )
Evolutionary StageEukaryota
AlphaFoldDBQ8IYX1
Gene CardTBC1D21
Uniprot IDQ8IYX1
PfamPF00566
In ASDno
Allosteric Predictionno (-1.423521385)
Ortholog in AnimalsAlpaca_ TBC1D21 ( ortholog_one2one )
Dog_ TBC1D21 ( ortholog_one2one )
GuineaPig_ TBC1D21 ( ortholog_one2one )
Macaque_ TBC1D21 ( ortholog_one2one )
Mouse_ Tbc1d21 ( ortholog_one2one )
Pig_ TBC1D21 ( ortholog_one2one )
Rat_ Tbc1d21 ( ortholog_one2one )
OhnologsNA
ParalogsTBC1D3C, TBC1D3D, TBC1D3, TBC1D3G, TBC1D3B, TBC1D3F, TBC1D3I, TBC1D3E, TBC1D3L, TBC1D3H, TBC1D3K, TBC1D8, TBC1D14, TBC1D10A, SGSM1, TBC1D8B, TBC1D2B, TBC1D10B, RABGAP1, TBC1D17, TBC1D9B, TBC1D25, TBC1D30, TBC1D26, TBC1D28, TBC1D22A, USP6NL, TBC1D9, RABGAP1L, TBC1D2, TBC1D13, TBC1D12, SGSM2, TBC1D4, GRTP1, EVI5, EVI5L, TBC1D15, SGSM3, TBC1D16, TBCK, TBC1D22B, TBC1D5, TBC1D1, TBC1D10C
Tissuetestis
Tissue SpecificityExpressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain. {ECO:0000269|PubMed:21128978, ECO:0000269|PubMed:33536340}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs16958445 
Subcellular location [CC]Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D9D3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9D9D3}. Note=Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids. {ECO:0000250|UniProtKB:Q9D9D3}.
Mouse PG classificationNA
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