Gene Information
Gene NameTBC1D2
OrganismHomo sapiens (Human)
Gene Length928
Protein NamesTBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000095383 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9BYX2
Gene CardTBC1D2
Uniprot IDQ9BYX2
PfamPF00169; PF00566
In ASDno
Allosteric Predictionno (-0.537273315)
Ortholog in AnimalsAlpaca_ TBC1D2 ( ortholog_one2one )
Dog_ TBC1D2 ( ortholog_one2one )
GuineaPig_ TBC1D2 ( ortholog_one2one )
Macaque_ TBC1D2 ( ortholog_one2one )
Mouse_ Tbc1d2 ( ortholog_one2one )
Pig_ TBC1D2 ( ortholog_one2one )
Rat_ Tbc1d2 ( ortholog_one2one )
Rabbit_ TBC1D2 ( ortholog_one2one )
OhnologsTBC1D2B
ParalogsTBC1D3C, TBC1D3D, TBC1D3, TBC1D3G, TBC1D3B, TBC1D3F, TBC1D3I, TBC1D3E, TBC1D3L, TBC1D3H, TBC1D3K, TBC1D8, TBC1D14, TBC1D10A, SGSM1, TBC1D8B, TBC1D2B, TBC1D10B, RABGAP1, TBC1D17, TBC1D9B, TBC1D25, TBC1D30, TBC1D26, TBC1D28, TBC1D22A, USP6NL, TBC1D9, RABGAP1L, TBC1D13, TBC1D12, SGSM2, TBC1D4, GRTP1, EVI5, EVI5L, TBC1D15, SGSM3, TBC1D16, TBCK, TBC1D22B, TBC1D5, TBC1D1, TBC1D10C, TBC1D21
Tissuelung, tongue, zone.of.skin
Tissue SpecificityExpressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level). {ECO:0000269|PubMed:11785977, ECO:0000269|PubMed:20116244}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DHK  (NMR  -  ) 
DBSNP rs879368  rs879369  rs1573025 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20116244}. Cytoplasmic vesicle {ECO:0000269|PubMed:20116244}. Cell junction {ECO:0000269|PubMed:20116244}.
Mouse PG classificationNA
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