| Gene Information | |
|---|---|
| Gene Name | UBE2O |
| Organism | Homo sapiens (Human) |
| Gene Length | 1292 |
| Protein Names | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000175931 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9C0C9 |
| Gene Card | UBE2O |
| Uniprot ID | Q9C0C9 |
| Pfam | PF00179 |
| In ASD | no |
| Allosteric Prediction | no (-1.032785417) |
| Ortholog in Animals | Alpaca_ UBE2O ( ortholog_one2one ) GuineaPig_ UBE2O ( ortholog_one2one ) Macaque_ UBE2O ( ortholog_one2one ) Mouse_ Ube2o ( ortholog_one2one ) Pig_ UBE2O ( ortholog_one2one ) Rat_ Ube2o ( ortholog_one2one ) Rabbit_ UBE2O ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBE2T, UBE2B, UBE2J2, UBE2A, UBE2C, UBE2H, UBE2V1, UBE2K, UBE2W, UBE2Z, UBE2F, UBE2G2, UBE2I, UBE2V2, UBE2N, UBE2NL, PEDS1, UBE2U, UBE2J1, UBE2G1, UBE2S, CDC34, UBE2R2, AKTIP |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11311559}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7UN3 (EM 3.50A ) 7UN6 (EM 3.30A ) |
| DBSNP | rs3803739 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:24703950}. Note=Mainly localizes to the cytoplasm. |
| Mouse PG classification | NA |
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