| Gene Information | |
|---|---|
| Gene Name | TASL |
| Organism | Homo sapiens (Human) |
| Gene Length | 301 |
| Protein Names | TLR adapter interacting with SLC15A4 on the lysosome |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000120280 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9HAI6 |
| Gene Card | TASL |
| Uniprot ID | Q9HAI6 |
| Pfam | PF15133 |
| In ASD | no |
| Allosteric Prediction | no (-1.411013637) |
| Ortholog in Animals | Alpaca_ TASL ( ortholog_one2one ) Alpaca_ TASL ( ortholog_one2many ) GuineaPig_ TASL ( ortholog_one2one ) Macaque_ TASL ( ortholog_one2one ) Mouse_ Tasl ( ortholog_one2one ) Pig_ TASL ( ortholog_one2one ) Rat_ Tasl ( ortholog_one2one ) Rabbit_ TASL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | lung, spleen |
| Tissue Specificity | Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level) (PubMed:31092820, PubMed:31001245). Expressed at low levels in T-cells and NK cells (PubMed:31001245). {ECO:0000269|PubMed:31001245, ECO:0000269|PubMed:31092820}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}. Endosome membrane {ECO:0000269|PubMed:32433612}. Nucleus {ECO:0000269|PubMed:31092820}. Cytoplasm {ECO:0000269|PubMed:31092820}. Note=Recruited to endolysosome following interaction with SLC15A4 (PubMed:32433612). May colocalize with TLR7 in the endosomal pathway (PubMed:31092820). {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}. |
| Mouse PG classification | NA |
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