| Gene Information | |
|---|---|
| Gene Name | NDUFS4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 175 |
| Protein Names | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit) |
| Target Name | nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000164258 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O43181 |
| Gene Card | NDUFS4 |
| Uniprot ID | O43181 |
| Pfam | PF04800 |
| In ASD | no |
| Allosteric Prediction | no (-0.512096844) |
| Ortholog in Animals | Alpaca_ NDUFS4 ( ortholog_one2one ) Macaque_ NDUFS4 ( ortholog_one2one ) Mouse_ Ndufs4 ( ortholog_one2one ) Pig_ NDUFS4 ( ortholog_one2one ) Rat_ Ndufs4 ( ortholog_one2one ) Rabbit_ NDUFS4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WDR93 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.359685(Chimpanzee);0.329993(Mouse);NULL(Rat);0.262308(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5XTB (EM 3.40A ) 5XTD (EM 3.70A ) 5XTH (EM 3.90A ) 5XTI (EM 17.40A ) |
| DBSNP | rs747359752 rs1044692 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:11181577, ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:31206022}; Peripheral membrane protein {ECO:0000269|PubMed:12611891}; Matrix side {ECO:0000269|PubMed:12611891}. Note=The interaction with BCAP31 mediates mitochondria localization. {ECO:0000269|PubMed:31206022}. |
| Mouse PG classification | HPG |
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