| Gene Information | |
|---|---|
| Gene Name | ECT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 914 |
| Protein Names | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000114346 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H8V3 |
| Gene Card | ECT2 |
| Uniprot ID | Q9H8V3 |
| Pfam | PF00533; PF12738; PF00621 |
| In ASD | no |
| Allosteric Prediction | yes (0.180558611) |
| Ortholog in Animals | Alpaca_ ECT2 ( ortholog_one2one ) Dog_ ECT2 ( ortholog_one2one ) GuineaPig_ ECT2 ( ortholog_one2one ) Macaque_ ECT2 ( ortholog_one2one ) Mouse_ Ect2 ( ortholog_one2one ) Pig_ ECT2 ( ortholog_one2one ) Rat_ Ect2 ( ortholog_one2one ) Rabbit_ ECT2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma. {ECO:0000269|PubMed:19617897}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3L46 (X-ray 1.48A ) 4N40 (X-ray 3.11A ) 6L30 (X-ray 2.80A ) |
| DBSNP | rs34703432 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19617897}. Cytoplasm {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16394104}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:17115030, ECO:0000269|PubMed:19468300}. Cleavage furrow {ECO:0000269|PubMed:10579713}. Midbody {ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:16394104, ECO:0000269|PubMed:17115030}. Cell junction {ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:16495035}. Cell junction, tight junction {ECO:0000269|PubMed:15254234}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17115030}. Note=Sequestered within the nucleus during interphase (PubMed:10579713). Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis (PubMed:10579713). Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis (PubMed:10579713). Colocalized with RhoA at the midbody (PubMed:10579713). Its subcellular localization to tight junction is increased by calcium (PubMed:15254234). {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:15254234}. |
| Mouse PG classification | NA |
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