| Gene Information | |
|---|---|
| Gene Name | TAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 748 |
| Protein Names | Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein) (RING4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000168394 ) 3 ( ENSG00000206297 ) 3 ( ENSG00000224212 ) 3 ( ENSG00000224748 ) 3 ( ENSG00000226173 ) 3 ( ENSG00000227816 ) 3 ( ENSG00000230705 ) 3 ( ENSG00000232367 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q03518 |
| Gene Card | TAP1 |
| Uniprot ID | Q03518 |
| Pfam | PF00664; PF00005 |
| In ASD | no |
| Allosteric Prediction | no (-0.605392361) |
| Ortholog in Animals | Alpaca_ TAP1 ( ortholog_one2one ) Dog_ PSMB8 ( ortholog_one2one ) GuineaPig_ TAP1 ( ortholog_one2one ) Macaque_ PSMB8 ( ortholog_one2one ) Mouse_ Tap1 ( ortholog_one2one ) Pig_ TAP1 ( ortholog_one2one ) Rat_ Tap1 ( ortholog_one2one ) Rabbit_ TAP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ABCB6, ABCB11, ABCB4, ABCB9, ABCB8, TAP2, ABCB7, ABCB1, ABCB10, ABCB5 |
| Tissue | NA |
| Tissue Specificity | Higly expressed in professional APCs monocytes and dendritic cells as well as in lymphocyte subsets T cells, B cells and NK cells. {ECO:0000269|PubMed:25656091, ECO:0000269|PubMed:9310490}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1JJ7 (X-ray 2.40A ) 5U1D (EM 3.97A ) |
| DBSNP | rs375389015 rs57640466 rs2228108 rs36229525 rs2228111 rs1057141 rs2127679 rs2228110 rs41550019 rs41561219 rs1135216 rs1057149 rs121917702 rs1057149 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:1589036, ECO:0000269|PubMed:22638925}; Multi-pass membrane protein {ECO:0000255}. Note=The transmembrane segments seem to form a pore in the membrane. |
| Mouse PG classification | LPG |
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