Gene Information
Gene NameTMEM175
OrganismHomo sapiens (Human)
Gene Length504
Protein NamesEndosomal/lysosomal proton channel TMEM175 (Transmembrane protein 175) (hTMEM175)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000127419 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9BSA9
Gene CardTMEM175
Uniprot IDQ9BSA9
PfamPF06736
In ASDno
Allosteric Predictionno (-0.999977876)
Ortholog in AnimalsAlpaca_ TMEM175 ( ortholog_one2one )
Dog_ TMEM175 ( ortholog_one2one )
GuineaPig_ TMEM175 ( ortholog_one2one )
Macaque_ TMEM175 ( ortholog_one2one )
Mouse_ Tmem175 ( ortholog_one2one )
Pig_ TMEM175 ( ortholog_one2one )
Rat_ Tmem175 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:26317472}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6W8N  (EM  3.20A  6W8O  (EM  3.40A  6W8P  (EM  3.60A  6WC9  (EM  2.64A  6WCA  (EM  3.03A  6WCB  (EM  3.17A  6WCC  (EM  3.24A  7LF6  (EM  3.50A  7UNL  (EM  2.45A  7UNM  (EM  2.61A 
DBSNP rs34884217  rs34311866 
Subcellular location [CC]Endosome membrane {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:32228865};
Multi-pass membrane protein {ECO:0000269|PubMed:32228865}. Lysosome membrane {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:31261387, ECO:0000269|PubMed:31658403, ECO:0000269|PubMed:32228865};
Multi-pass membrane protein {ECO:0000269|PubMed:32228865}.
Mouse PG classificationNA
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