| Gene Information | |
|---|---|
| Gene Name | TAN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2555 |
| Protein Names | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P46531 |
| Gene Card | NOTCH1 |
| Uniprot ID | P46531 |
| Pfam | PF12796; PF00008; PF07645; PF12661; PF06816; PF07684; PF00066 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PB5 (NMR - ) 1TOZ (NMR - ) 1YYH (X-ray 1.90A ) 2F8X (X-ray 3.25A ) 2F8Y (X-ray 1.55A ) 2HE0 (X-ray 1.90A ) 2VJ3 (X-ray 2.60A ) 3ETO (X-ray 2.00A ) 3I08 (X-ray 3.20A ) 3L95 (X-ray 2.19A ) 3NBN (X-ray 3.45A ) 3V79 (X-ray 3.85A ) 4CUD (X-ray 1.85A ) 4CUE (X-ray 3.00A ) 4CUF (X-ray 2.29A ) 4D0E (X-ray 1.61A ) 4D0F (X-ray 2.80A ) 5FM9 (X-ray 2.92A ) 5FMA (X-ray 2.46A ) 5KZO (NMR - ) 5L0R (X-ray 1.50A ) 5UB5 (X-ray 2.09A ) 6IDF (EM 2.70A ) 6PY8 (X-ray 3.75A ) |
| DBSNP | rs11574885 rs587777736 rs11574895 rs587781259 rs2229968 rs587777734 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q01705}; Single-pass type I membrane protein {ECO:0000305|PubMed:30598546}.; [Notch 1 intracellular domain]: Nucleus {ECO:0000250|UniProtKB:Q01705}. Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. {ECO:0000250|UniProtKB:Q01705}. |
| Mouse PG classification | NA |
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