| Gene Information | |
|---|---|
| Gene Name | TAK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 606 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O43318 |
| Gene Card | MAP3K7 |
| Uniprot ID | O43318 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form. {ECO:0000269|PubMed:11118615}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001810(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EVA (X-ray 2.00A ) 2YIY (X-ray 2.49A ) 4GS6 (X-ray 2.20A ) 4L3P (X-ray 2.68A ) 4L52 (X-ray 2.54A ) 4L53 (X-ray 2.55A ) 4O91 (X-ray 2.39A ) 5E7R (X-ray 2.11A ) 5GJD (X-ray 2.79A ) 5GJF (X-ray 2.89A ) 5GJG (X-ray 2.61A ) 5J7S (X-ray 2.37A ) 5J8I (X-ray 2.40A ) 5J9L (X-ray 2.75A ) 5JGA (X-ray 2.00A ) 5JGB (X-ray 2.80A ) 5JGD (X-ray 3.10A ) 5JH6 (X-ray 2.37A ) 5JK3 (X-ray 2.37A ) 5V5N (X-ray 2.01A ) 7NTH (X-ray 1.97A ) 7NTI (X-ray 1.98A ) |
| DBSNP | rs886039236 rs886039231 rs886039232 rs886039235 rs886039233 rs886039237 rs201721045 rs886039230 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12242293}. Cell membrane {ECO:0000269|PubMed:12242293}; Peripheral membrane protein {ECO:0000269|PubMed:12242293}; Cytoplasmic side {ECO:0000269|PubMed:12242293}. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane. |
| Mouse PG classification | NA |
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