| Gene Information | |
|---|---|
| Gene Name | GEC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 117 |
| Protein Names | Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H0R8 |
| Gene Card | GABARAPL1 |
| Uniprot ID | Q9H0R8 |
| Pfam | PF02991 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta. {ECO:0000269|PubMed:11374880, ECO:0000269|PubMed:11414770, ECO:0000269|PubMed:23690988}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.174523(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L8J (NMR - ) 2R2Q (X-ray 1.65A ) 5DPT (X-ray 2.90A ) 5LXH (X-ray 1.58A ) 5LXI (X-ray 1.44A ) 6HOI (X-ray 1.14A ) 6HOL (X-ray 1.40A ) 6YOO (X-ray 1.06A ) 7AA7 (X-ray 1.45A ) 7AA9 (X-ray 1.72A ) 7JHX (X-ray 1.91A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:30661429, ECO:0000305|PubMed:23690988}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:20404487}; Lipid-anchor {ECO:0000269|PubMed:20404487}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q0VGK0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q0VGK0}. Golgi apparatus {ECO:0000250|UniProtKB:Q0VGK0}. |
| Mouse PG classification | NA |
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