| Gene Information | |
|---|---|
| Gene Name | MENA |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | Protein enabled homolog |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8N8S7 |
| Gene Card | ENAH |
| Uniprot ID | Q8N8S7 |
| Pfam | PF08776; PF00568 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. {ECO:0000269|PubMed:15027125}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HO2 (X-ray 1.33A ) 2IYB (X-ray 2.35A ) 2XQN (X-ray 2.62A ) 4MY6 (X-ray 1.70A ) 5N91 (X-ray 1.49A ) 5N9C (X-ray 1.16A ) 5N9P (X-ray 1.80A ) 5NAJ (X-ray 1.46A ) 5NBF (X-ray 1.15A ) 5NBX (X-ray 1.65A ) 5NC2 (X-ray 1.58A ) 5NC7 (X-ray 2.70A ) 5NCF (X-ray 1.40A ) 5NCG (X-ray 1.02A ) 5NCP (X-ray 1.65A ) 5ND0 (X-ray 1.45A ) 5NDU (X-ray 1.42A ) 5NEG (X-ray 1.29A ) 6RCF (X-ray 1.10A ) 6RCJ (X-ray 1.35A ) 6RD2 (X-ray 1.00A ) 6XVT (X-ray 1.40A ) 6XXR (X-ray 1.48A ) 7A5M (X-ray 0.78A ) 7AKI (X-ray 1.36A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Synapse {ECO:0000250}. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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