Gene Information
Gene NameMAD2L1
OrganismHomo sapiens (Human)
Gene Length205
Protein NamesMitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000164109 )
Evolutionary StageEukaryota
AlphaFoldDBQ13257
Gene CardMAD2L1
Uniprot IDQ13257
PfamPF02301
In ASDno
Allosteric Predictionno (-0.278359644)
Ortholog in AnimalsAlpaca_ MAD2L1 ( ortholog_one2one )
Alpaca_ MAD2L1 ( ortholog_one2many )
GuineaPig_ MAD2L1 ( ortholog_one2one )
Mouse_ Mad2l1 ( ortholog_one2one )
Pig_ MAD2L1 ( ortholog_one2one )
Rat_ Mad2l1 ( ortholog_one2one )
Rabbit_ MAD2L1 ( ortholog_one2one )
OhnologsNA
ParalogsMAD2L2
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.073529(Chimpanzee);0.261983(Mouse);0.357772(Rat);0.151837(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1DUJ  (NMR  -  )  1GO4  (X-ray  2.05A  )  1KLQ  (NMR  -  )  1S2H  (NMR  -  )  2QYF  (X-ray  2.30A  )  2V64  (X-ray  2.90A  )  2VFX  (X-ray  1.95A  )  3GMH  (X-ray  3.95A  )  5KHU  (EM  4.80A  )  5LCW  (EM  4.00A  )  6F0X  (EM  4.60A  )  6TLJ  (EM  3.80A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:19010891}. Chromosome, centromere, kinetochore. Cytoplasm {ECO:0000269|PubMed:19010891}. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. Sequestered to the cytoplasm upon interaction with isoform 3 of MAD1L1 (PubMed:19010891). {ECO:0000269|PubMed:19010891, ECO:0000305}.
Mouse PG classificationNA
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