| Gene Information | |
|---|---|
| Gene Name | SLC30A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 369 |
| Protein Names | Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000164756 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8IWU4 |
| Gene Card | SLC30A8 |
| Uniprot ID | Q8IWU4 |
| Pfam | PF01545 |
| In ASD | no |
| Allosteric Prediction | yes (0.225876025) |
| Ortholog in Animals | Alpaca_ SLC30A8 ( ortholog_one2one ) Dog_ SLC30A8 ( ortholog_one2one ) Macaque_ SLC30A8 ( ortholog_one2one ) Mouse_ Slc30a8 ( ortholog_one2one ) Pig_ SLC30A8 ( ortholog_one2one ) Rat_ Slc30a8 ( ortholog_one2one ) Rabbit_ SLC30A8 ( ortholog_one2one ) |
| Ohnologs | SLC30A3, SLC30A2 |
| Paralogs | SLC30A2, SLC30A3, SLC30A10, SLC30A1, SLC30A7, SLC30A4, SLC30A6, SLC30A5 |
| Tissue | pancreas |
| Tissue Specificity | In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16158222, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:17118530, ECO:0000269|PubMed:17971500}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6XPD (EM 3.80A ) 6XPE (EM 4.10A ) 6XPF (EM 5.90A ) |
| DBSNP | rs16889462 rs13266634 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000269|PubMed:15331542}. |
| Mouse PG classification | HPG |
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