| Gene Information | |
|---|---|
| Gene Name | TACR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 407 |
| Protein Names | Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) |
| Target Name | neurokinin 1 receptor |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000115353 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P25103 |
| Gene Card | TACR1 |
| Uniprot ID | P25103 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.290478777) |
| Ortholog in Animals | Alpaca_ TACR1 ( ortholog_one2one ) Dog_ TACR1 ( ortholog_one2one ) GuineaPig_ TACR1 ( ortholog_one2one ) Macaque_ TACR1 ( ortholog_one2one ) Mouse_ Tacr1 ( ortholog_one2one ) Pig_ TACR1 ( ortholog_one2one ) Rat_ Tacr1 ( ortholog_one2one ) Rabbit_ TACR1 ( ortholog_one2one ) |
| Ohnologs | TACR2, TACR3 |
| Paralogs | TACR3, TACR2, OR9A2, NPY1R, MTNR1B, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, GPR75, OR11G2, MCHR2, MCHR1, GPR19, OR11A1, OR11H2, OR11H12, OR11H1, GPR83, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2, NPY4R |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KS9 (NMR - ) 2KSA (NMR - ) 2KSB (NMR - ) 6E59 (X-ray 3.40A ) 6HLL (X-ray 3.27A ) 6HLO (X-ray 2.40A ) 6HLP (X-ray 2.20A ) 7P00 (EM 2.71A ) 7P02 (EM 2.87A ) 7RMG (EM 3.00A ) 7RMH (EM 3.10A ) 7RMI (EM 3.20A ) |
| DBSNP | rs200685841 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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