| Gene Information | |
|---|---|
| Gene Name | TACC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 805 |
| Protein Names | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000147526 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75410 |
| Gene Card | TACC1 |
| Uniprot ID | O75410 |
| Pfam | PF05010 |
| In ASD | no |
| Allosteric Prediction | no (-1.265162486) |
| Ortholog in Animals | Alpaca_ TACC1 ( ortholog_one2one ) Dog_ TACC1 ( ortholog_one2one ) GuineaPig_ TACC1 ( ortholog_one2one ) Macaque_ TACC1 ( ortholog_one2one ) Mouse_ Tacc1 ( ortholog_one2one ) Rat_ Tacc1 ( ortholog_one2one ) Rabbit_ TACC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TACC3, TACC2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. {ECO:0000269|PubMed:12165861, ECO:0000269|PubMed:12547166}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34235313 rs6980553 rs10107016 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14767476}. Nucleus {ECO:0000269|PubMed:14767476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21531210}. Midbody {ECO:0000269|PubMed:21531210}. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.; [Isoform 5]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.; [Isoform 10]: Cytoplasm {ECO:0000269|PubMed:20078863}. |
| Mouse PG classification | NA |
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